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Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 502-508 doi: 10.1007/s11684-017-0590-z
Although the efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitis
Keywords: chronic hepatitis B serum HBV RNA nucleos(t)ide analogs virological response para-functional cure
Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang
Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1, Pages 1-15 doi: 10.1007/s11705-016-1562-6
Keywords: synthesis marine drugs tricyclic pyrroloquinone alkaloid cancer therapy MDM2 p53
Zhuoying WU, Qing WANG, Feng GUO, Shenghua ZHANG, Qipei JIANG, Xin YU
Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2, Pages 205-214 doi: 10.1007/s11783-013-0492-5
Keywords: drinking water distribution systems (DWDS) biofilm quorum sensing (QS) N-acyl-L-homoserine lactones (AHLs) (dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) 2(5H)-furanone
Deubiquitinases as pivotal regulators of T cell functions
Xiao-Dong Yang, Shao-Cong Sun
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 451-462 doi: 10.1007/s11684-018-0651-y
T cells efficiently respond to foreign antigens to mediate immune responses against infections butDefect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potentialThis review will discuss the recent progresses regarding the functions of DUBs in T cells.
Keywords: deubiquitinase ubiquitination T cell activation T cell differentiation T cell tolerance
Regulation of T cell immunity by cellular metabolism
Zhilin Hu, Qiang Zou, Bing Su
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 463-472 doi: 10.1007/s11684-018-0668-2
T cells are an important adaptive immune response arm that mediates cell-mediated immunity.T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effectorSpecific metabolic programs are tightly controlled to mediate T cell immune responses, and alterationsin T cell metabolism may result in many immunological disorders.in T cell metabolic programming during T cell homeostasis, differentiation, and function.
Keywords: T cell immunity metabolic pathways nutrient uptake metabolic checkpoints
Separation and extraction of bridge dynamic strain data
Baijian WU, Zhaoxia LI, Ying WANG, T. H. T. CHAN,
Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4, Pages 395-400 doi: 10.1007/s11709-009-0049-7
Keywords: dynamic valuable separatrix strain/stress amplitude frequency
Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome
Guangbiao Zhou, Xinchun Zhao
Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 236-238 doi: 10.1007/s11684-017-0611-y
Recently, Ng . reported that the A:T>T:A substitutions, proposed to be a signature of aristolochicof the patients’ exposure history is the key to determine the “culprit” of the A:T>T:A mutations.
Keywords: genomic signature carcinogen aristolochic acid tobacco smoke vinyl chloride hepatocellular carcinoma
Xuefu Wang, Zhigang Tian
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 262-268 doi: 10.1007/s11684-017-0584-x
γδ T cells display unique developmental, distributional, and functional patterns and canγδ T cells are enriched in the liver and exhibit liver-specific features.In this study, we review the properties of hepatic γδ T cells and summarize the roles ofγδ T cells in liver diseases.We believe that determining the properties and functions of γδ T cells in liver diseases
Keywords: γδT cells liver infection non-alcoholic fatty liver disease autoimmune hepatitis liver fibrosis and cirrhosis
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 69-82 doi: 10.1007/s11684-018-0677-1
Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapyThe low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT).TCR-CATs delivered significantly better activation and cytotoxicity than the equivalent TCR-engineered TTCR-CAT may be a very good alternative to the expensive TCR-T, which is considered an effective personalized
Keywords: cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT
Ian T. RILEY
Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4, Pages 568-582 doi: 10.15302/J-FASE-2019270
Keywords: actinorrhizal trees agroforestry climate change ecosystem restoration
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 783-804 doi: 10.1007/s11684-021-0904-z
Keywords: CAR T cells hematological malignancies review
Chimeric antigen receptor T cell therapies for acute myeloid leukemia
Bin Gu, Jianhong Chu, Depei Wu
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 701-710 doi: 10.1007/s11684-020-0763-z
Keywords: acute myeloid leukemia CAR T immunotherapy
Innate and adaptive T cells in influenza disease
Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska
Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 34-47 doi: 10.1007/s11684-017-0606-8
Keywords: influenza innate T cells CD4+ and CD8+ T cells vaccination
Treating wastewater under zero waste principle using wetland mesocosms
Ezzat, Mohammed T. Mohammed T.
Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1351-9
Keywords: Wastewater dynamic roughing filter Cyperus papyrus (L.) zeolite zero waste
Modeling of alkali-silica reaction in concrete: a review
PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN
Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 1, Pages 1-18 doi: 10.1007/s11709-012-0141-2
Keywords: alkali-silica reaction (ASR) modeling concrete mesoscopic macroscopic
Title Author Date Type Operation
Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ideanalogs
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Journal Article
Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer
Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang
Journal Article
bacterial strains isolated from drinking water environments to N-acyl-L-homoserine lactones and their analogs
Zhuoying WU, Qing WANG, Feng GUO, Shenghua ZHANG, Qipei JIANG, Xin YU
Journal Article
Deubiquitinases as pivotal regulators of T cell functions
Xiao-Dong Yang, Shao-Cong Sun
Journal Article
Separation and extraction of bridge dynamic strain data
Baijian WU, Zhaoxia LI, Ying WANG, T. H. T. CHAN,
Journal Article
Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome
Guangbiao Zhou, Xinchun Zhao
Journal Article
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
Journal Article
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies
Journal Article
Chimeric antigen receptor T cell therapies for acute myeloid leukemia
Bin Gu, Jianhong Chu, Depei Wu
Journal Article
Innate and adaptive T cells in influenza disease
Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska
Journal Article
Treating wastewater under zero waste principle using wetland mesocosms
Ezzat, Mohammed T. Mohammed T.
Journal Article